3-(arylsulfonylamino)-tetrahydrofuran-3-carboxylic acid...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 307/24 (2006.01) A61K 31/341 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2375513

A compound of formula (I) wherein R1, R2 and Q are as defined above, are useful in the treatment of an arthritis (including osteoarthritis and rheumatoid arthritis), cancer (such as solid tumor cancer including colon cancer, breast cancer, lung cancer and prostrate cancer and hematopoietic malignancies including leukemias and lymphomas), and other disorders. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID' S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

La présente invention concerne des composés de formule (I) dans laquelle R<1>, R<2> et Q sont tels que définis ci-dessus. Ces composés sont utilisés dans le traitement de l'arthrite (comprenant l'ostéo-arthrite et la polyarthrite rhumatoïde), du cancer (tel que le cancer à tumeur solide comprenant le cancer du colon, le cancer du sein, le cancer du poumon et le cancer de la prostate, ainsi que les proliférations malignes telles que les leucémies et les lymphomes) et d'autres troubles. De plus, les composés selon cette invention peuvent être utilisés en traitement combiné avec des médicaments anti-inflammatoires non-stéroïdiens classiques (NSAID) et des analgésiques. Ces composés peuvent également être utilisés en combinaison avec des médicaments cytotoxiques, tels que le chlorhydrate de doxorubicine, la daunomycine, le cisplatine, l'étoposide, le taxol, le taxotère, et d'autres alcaloïdes, tels que la vincristine, dans le traitement du cancer.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

3-(arylsulfonylamino)-tetrahydrofuran-3-carboxylic acid... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-(arylsulfonylamino)-tetrahydrofuran-3-carboxylic acid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-(arylsulfonylamino)-tetrahydrofuran-3-carboxylic acid... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1354306

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.