3-(arylsulfonylamino)-tetrahydropyran-3-carboxylic acid...

C - Chemistry – Metallurgy – 07 – D

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C07D 309/14 (2006.01) A61K 31/351 (2006.01) A61P 35/00 (2006.01) C07D 309/28 (2006.01)

Patent

CA 2375524

A compound of formula (I) wherein R1, R2, R3, R4 and Q are as defined above, are useful in the treatment of arthritis (including osteoarthritis and rheumatoid arthritis), cancer and other diseases. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti- inflammatory drugs (NSAID's), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

La présente invention concerne un composé représenté par la formule générale (I) dans laquelle R<1>, R<2>, R<3>, R<4> et Q sont tels que définis ci-dessus. De tels composés conviennent particulièrement au traitement de l'arthrite, y-compris de l'ostéoarthrite et de l'arthrite rhumatoïde, mais aussi du cancer et d'autres affections. En outre, le composé de l'invention convient en thérapie combinée faisant intervenir des anti-inflammatoires non stéroïdiens standards, des inhibiteurs de la cyclooxygénase 2, et des analgésiques, et en association avec des cytotoxiques tels que l'adriamycine, la daunomycine, le cis-platine, les étoposides, taxol, taxotère et autres alcaloïdes tels que la vincritine dans le cadre d'une thérapie anticancéreuse.

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