3-aza-6,8-dioxabicyclo[3.2.1]octanes and analogues and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 498/08 (2006.01) C07D 241/00 (2006.01) C07D 263/00 (2006.01) C07D 265/00 (2006.01) C07D 317/00 (2006.01) C07D 513/08 (2006.01)

Patent

CA 2401693

The present invention relates to new highly functionalized heterobicycle derivatives of general formula (I), prepared by a process which involves only two steps by using, as starting products, commercially available, or easily prepared, .alpha.-amino ketones and .alpha.,.beta.-dihydroxy acids or .alpha.- amino-.beta.-hydroxy acids or .alpha.-hydroxy-.beta.-amino acids or .alpha.,.beta.-dithiol acids derivatives and to libraries containing compounds of formula (I) and to the generation of such combinatorial libraries composed of compounds of formula (I), in individual synthesis, mixture synthesis, split and recombine synthesis and parallel synthesis either in manual or automated fashion.

La présente invention se rapporte à de nouveaux dérivés hétérobicycliques hautement fonctionnalisés de la formule générale (I) préparés selon un processus en deux étapes seulement dans lequel on utilise comme produits de base des .alpha.-amino-cétones et des acides .alpha.,.beta.-dihydroxy ou des acides .alpha.-amino-.beta.-hydroxy ou des acides .alpha.-hydroxy-.beta.-amino ou des dérivés d'acides .alpha.,.beta.-dithiol disponibles dans le commerce ou faciles à préparer, et à des bibliothèques contenant des composés de la formule (I) et à la production de ces bibliothèques combinatoires composées de composés de la formule (I) en synthèse individuelle, en synthèse de mélange, en synthèse de division et recombinaison et en synthèse parallèle, en mode manuel ou automatisé.

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