3-azabicyclo (3.1.0) hexane derivatives as opioid receptor...

Details 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor... 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor...

C - Chemistry, Metallurgy

07

D

C07D 209/52 (2006.01) A61K 31/403 (2006.01) A61K 31/4178 (2006.01) C07D 303/04 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2463264

The subject invention provides a compound of the formula (I), wherein X, Q, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined. Compounds of formula (I) have activity as opioid receptor antagonists. The subject invention furthermore provides for pharmaceutical compositions and therapeutic methods comprising compounds of formula (I).

L'invention concerne un composé de formule (I), dans laquelle X, Q, n, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, et R?10¿ sont définis dans la description. Les composés de formule (I) possèdent une activité d'antagoniste de récepteur opioïde. L'invention concerne aussi des compositions pharmaceutiques et des méthodes de soins thérapeutiques mettant en oeuvre des composés de formule (I).

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