C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/404 (2006.01)
Patent
CA 2673368
Compounds of formula (I): and pharmaceutically acceptable salts, esters and solvates thereof, where variables are defined in the specification, useful generally as inhibitors of protein kinases and particularly useful for inhibition of GSK-3. Pharmaceutically compositions and medicaments containing a compound of the invention are provided. The invention provides methods of treatment of protein kinase-related disease, disorders or conditions. The invention provides methods of treatment of GSK-3-related diseases, disorders or conditions. More specifically, methods of treatment of bipolar disorder, including mania, schizophrenia, stroke, epilepsy, motor neuron disease, cranial or spinal trauma, neurodegenerative disorders, including multiple sclerosis (MS), Alzheimer's disease, Fragile X syndrome, autism, Huntington's disease, Parkinson's
L'invention concerne des composés représentés par la formule (I) et des sels, esters et solvates pharmaceutiquement acceptables de ceux-ci, les variables étant définies dans le mémoire, généralement utiles comme inhibiteurs de protéine kinases et particulièrement utiles pour une inhibition de GSK-3. Des compositions pharmaceutiques et des médicaments contenant un composé de l'invention sont proposés. L'invention propose des procédés de traitement de maladies, troubles ou affections liés aux protéines kinases. L'invention propose des procédés de traitement de maladies, troubles ou affections liés au GSK-3. Plus spécifiquement, des procédés de traitement du trouble bipolaire, comprenant la manie, la schizophrénie, un accident vasculaire cérébral, l'épilepsie, la sclérose latérale amyotrophique, un traumatisme crânien ou spinal, des maladies neurodégnératives, comprenant la sclérose en plaques (MS), la maladie d'Alzheimer, le syndrome du X fragile, l'autisme, la maladie de Huntington et la maladie de Parkinson.
Gaysina Irina
Kozikowski Alan P.
Mckay-Carey & Company
The Board Of Trustees Of The University Of Illinois
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