3-benzoyl benzofuran derivatives as thyroid hormone antagonists

Details 3-benzoyl benzofuran derivatives as thyroid hormone antagonists 3-benzoyl benzofuran derivatives as thyroid hormone antagonists

C - Chemistry, Metallurgy

07

D

C07D 307/80 (2006.01) A61K 31/34 (2006.01)

Patent

CA 2197185

The invention provides compounds according to formula (I), in which: Ha = I or Br, X = CH2 or C = O, R1 = C1-4 alkyl, R2 = -NHSO2R3; -NHCOR3; or -NHCONHR3, where R3 = -CF3, C1-3 alkyl, 4-R4C6H4-; where R4 = C1-4 alkoxy-; hydroxy-; fluoro-; or nitro-; or a pharmaceutically acceptable salt thereof. The compounds may particularly be used in the treatment of T3 regulated gene disorders and diseases.

L'invention concerne des composés selon la formule (I), ou un sel de ceux-ci, acceptable sur le plan pharmaceutique, dans laquelle: Ha = I ou Br; X = CH¿2? ou C = O; R?1¿ = alkyle C¿1-4?; R?2¿ = -NHSO¿2?R?3¿, -NHCOR?3¿ ou -NHCONHR?3¿, où R?3¿ = -CF¿3?, alkyle C¿1-3?, 4-R?4¿C¿6?H¿4?-; où R?4¿ = alcoxy C¿1-4?, hydroxy, fluoro ou nitro.

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