C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/12 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2294772
3-Benzoylindole derivatives represented by general formula (I) wherein R1 represents lower alkyl; n is an integer of from 1 to 5; R2 and R3 represent each hydrogen, lower alkyl or optionally substituted phenyl; and R4 represents hydrogen or lower alkyl. Because of having a potent .alpha.1-adrenergic receptor blocking effect and a testosterone 5.alpha.-reductase inhibitory effect and showing a high safety, these compounds are useful as preventives and/or remedies for prostatic hypertrophy, urinary disorders in association with prostatic hypertrophy, baldness or acne.
L'invention concerne des dérivés de 3-benzoylindole de la formule générale (I) dans laquelle R?1¿ est alkyle inférieur; n est un entier compris entre 1 et 5; R?2¿ et R?3¿ sont chacun hydrogène, alkyle inférieur ou phényle éventuellement substitué; et R?4¿ est hydrogène ou alkyle inférieur. Ces composés ont un puissant effet d'inhibition du récepteur .alpha.¿1?-adrénergique et de la 5-.alpha.-réductase de la testostérone, et offrent un niveau de sécurité élevé, ce qui en fait des composés efficaces en tant que médicaments préventifs et/ou thérapeutiques contre l'hypertrophie prostatique, les troubles urinaires, la calvitie ou l'acné.
Chikazawa Jun
Fukuda Yoichi
Nagano Eiichi
Sato Hiroki
Takei Mineo
Gowling Lafleur Henderson Llp
Zeria Pharmaceutical Co. Ltd.
LandOfFree
3-benzoylindole derivatives and drugs containing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-benzoylindole derivatives and drugs containing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-benzoylindole derivatives and drugs containing the same will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1366172