3.beta.,17.beta.-hydroxy-substituted steroids and related...

Details 3.beta.,17.beta.-hydroxy-substituted steroids and related... 3.beta.,17.beta.-hydroxy-substituted steroids and related...

C - Chemistry, Metallurgy

07

J

167/198, 260/50

C07J 1/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2001264

The present invention is directed to a group of compounds which are 3.beta.,17.beta.-hydroxy steroids, and related steroidal structures. These compounds are aromatase inhibitors, and thus, regulate or inhibit the conversion of androgens to estrogens. These compounds may be utilized to treat conditions potentiated by the presence of estrogens. These compounds exhibit a slower onset of action and a longer half life relative to the 10-(2-alkynyl) steroidal aromatase inhibitors disclosed in U.S. Patent 4,322,416.

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