C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/30 (2006.01) A61K 31/137 (2006.01) A61K 31/381 (2006.01) A61K 31/4045 (2006.01) A61P 25/00 (2006.01) C07C 215/64 (2006.01) C07C 217/74 (2006.01) C07C 233/58 (2006.01) C07D 209/14 (2006.01) C07D 209/18 (2006.01) C07D 333/58 (2006.01) C07D 333/60 (2006.01)
Patent
CA 2368840
A pharmaceutical compound of formula (I) in which R1 and R2 are each hydrogen or C1-4 alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholino group, said group being optionally substituted with 1 to 3 C1-4 alkyl substituents, R3 is a naphthyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinolinyl or isoquinolinyl group, said group being optionally substituted, and n is 1 or 2; or a salt or ester thereof.
L'invention concerne un composé pharmaceutique de la formule (I), dans laquelle R?1¿ et R?2¿ représentent, chacun, un hydrogène ou un C¿1-4? alkyle, ou R?1¿ et R?2¿ ainsi que l'atome d'azote auquel ils sont fixés forment un groupe azétidinyle, pyrrolidinyle, pipéridinyle, pipérazinyle ou morpholino, ledit groupe étant facultativement substitué avec 1 à 3 substituants C¿1-4? alkyle; R?3¿ est un groupe naphtyle, indolyle, benzothiényle, benzofuranyle, benzothiazolyle, quinolinyle ou isoquinolinyle, ledit groupe étant facultativement substitué, et n est égal à 1 ou 2; ou un sel ou un ester de ces derniers.
Keenan Martine
Milutinovic Sandra Ginette
Tupper David Edward
Eli Lilly And Company Limited
Gowling Lafleur Henderson Llp
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