3-(biphenylyl and phenyloxy) butane-1-amine derivatives

Details 3-(biphenylyl and phenyloxy) butane-1-amine derivatives 3-(biphenylyl and phenyloxy) butane-1-amine derivatives

C - Chemistry, Metallurgy

07

D

260/390, 260/602

C07D 521/00 (2006.01) C07C 217/62 (2006.01) C07D 209/48 (2006.01) C07D 295/03 (2006.01) C07D 295/073 (2006.01) C07D 295/084 (2006.01) C07D 295/088 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1073907

Compounds of the formula Image wherein R is a 4-biphenylyl; 4-phenoxyphenyl; or 4-biphenylyl or 4-phenoxy- phenyl substituted 1 to 9 times by F, Cl and/or Br; A is -CH(CH3)-CH2(CH2)n-, -C(CH3)=CH-(CH2)n- or -C(OH)(CH3)-CH2-(CH2)n-; Z is -NR1R2, imidazol-1-yl, phthalimido or 3,4-dihydro-4-oxophthalazin-1-yl-amino, R1 and R2 each are H, alkyl, azaalkyl or acyl wherein alkyl and acyl in each instance being of 1 - 6 carbon atoms or, collectively, are alkylene of 4 - 7 carbon atoms, 3- oxapentamethylene or 3-R3-3-azapentamethylene, wherein R is H, alkyl or hydroxyalkyl in which alkyl in each instance is of up to 6 carbon atoms, and n is 1 or 2, and their physiologically acceptable acid addition salts are provided herein. Preferably they are produced by certain specified reduction reactions. The compounds possess anti-inflammatory, anti-arteriosclerotic and serum choles- terol and triglyceride level lowering activities.

238196

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