3-(bis-substituted phenylmethylene)oxindole derivatives

Details 3-(bis-substituted phenylmethylene)oxindole derivatives 3-(bis-substituted phenylmethylene)oxindole derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/40 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2214744

The present invention is directed to an oxindole derivative represented by formula (1): Image (wherein R represents a methyl group or a methoxy group), and pharmaceuticals containing the compound. The compound exhibits excellent granulation inhibiting activity while providing minimal liver toxicity and is useful as a pharmaceutical in the prevention and treatment of articular rheumatism, arteriosclerosis, hepatocirrhosis, etc., and also in the prevention and treatment of arthrosis deformans, psoriasis, gout, nephritis, angiitis, inflammatory intestinal diseases (ulcerative colitis, Crohn's disease), bronchitis, and chronic granulomatosis, etc.

Dérivés d'oxindole représentés par la formule générale (1) et médicaments les contenant, formule dans laquelle R représente méthyle ou méthoxy. Etant donné qu'ils représentent d'excellents effets inhibant la granulation avec une faible toxicité hépatique, ces composés sont utiles en tant que médicaments et utilisables dans la prévention et le traitement de rhumatismes articulaires, de l'artériosclérose, de la cirrhose épathique, de la polyarthrite rhumatoïde, du psoriasis, de la goutte, de la néphrite, de l'angéite, de maladies entérales inflammatoires (recto-colite hémorragique, de la maladie de Crohn), de la bronchite, de l'arthrite, de la granulomatose, etc.

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