3-carbamoyloxymethyl-7-(2-(fur-2-yl)-2-methoxyiminoacetamido...

C - Chemistry – Metallurgy – 07 – D

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260/104.1, 260/1

C07D 501/04 (2006.01) A61D 7/00 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/06 (2006.01) C07D 501/24 (2006.01) C07D 501/26 (2006.01) C07D 501/28 (2006.01) C07D 501/32 (2006.01) C07D 501/34 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1057283

ABSTRACT OF THE DISCLOSURE (6R,7R)-3-Carbamoyloxymethyl-7-[2-(fur-2-yl)- 2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acid of the formula Image (I) and its non-toxic salts, biologically acceptable esters, 1-oxides and solvates thereof, possess a particularly valuable combination of properties, exhibiting high antibacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms. and stability in vivo. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer. The compound of formula (I) may be prepared by (a) acylation of the corresponding 7-amino compound, or (b) carbamoylation of the corresponding 3-hydroxymethyl compound. - 1 -

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