C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/55 (2006.01) C07D 209/00 (2006.01) C07D 243/00 (2006.01)
Patent
CA 2268327
This invention relates to tricyclic non-peptide vaso- pressin antagonists which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure, in disease conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction, the com- pounds having general structure (I).
La présente invention concerne des antagonistes non peptidiques tricycliques de la vasopressine qui s'utilisent dans le traitement de troubles nécessitant une baisse du taux de vasopressine comme dans le cas de l'insuffisance cardiaque globale, de troubles liés à l'hyper-réabsorption d'eau par les reins, et de troubles liés à une augmentation de la résistance vasculaire et à la vasoconstriction coronaire. Ces composés présentent la structure générale (I).
Ashwell Mark Anthony
Bagli Jehan Framroz
Caggiano Thomas Joseph
Molinari Albert John
Trybulski Eugene John
American Home Products Corporation
Ridout & Maybee Llp
Wyeth
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