3-carboxypropyl-aminotetralin derivatives and related...

C - Chemistry – Metallurgy – 07 – C

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C07C 215/64 (2006.01) A61K 31/197 (2006.01) A61K 31/216 (2006.01) A61P 1/00 (2006.01) C07C 229/28 (2006.01) C07C 237/48 (2006.01)

Patent

CA 2707981

The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): (I) wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

L'invention concerne des composés de 3-carboxypropyl-aminotétraline de formule (I) : (I) où R1, R2, R3, R4, R5, et R6 sont définis dans la description, ou un sel pharmaceutiquement acceptable de ceux-ci, qui sont des antagonistes au niveau du récepteur mu-opioïde. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés, des procédés d'utilisation de tels composés pour traiter des affections associées avec une activité du récepteur mu-opioïde, et des procédés et des produits intermédiaires utiles pour préparer de tels composés.

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