C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/15
C07J 71/00 (2006.01)
Patent
CA 1202299
ABSTRACT OF THE DISCLOSURE New .DELTA.1,3,5-3-chloro-pregnane derivatives of the general formula (I), Image (I) wherein X is hydrogen atom, acetyl group or a chloroacetyl group, and Y and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of them is other than hydrogen, are prepared by reacting a .DELTA.1,4-3-oxo-pregnane de- rivative of the general formula,(II), Image (II) wherein X' is acetyl group or a chloroacetyl group and Y and Z are as defined above, with a chloromethyl- -2- eneiminium salt of the general formula (III), Image (III) wherein A(-) is a salt-forming anion, in an aprotic solvent in the presence of a tertiary base, and, if desired, subjecting the resulting product to hydro- lysis. The compounds of the general formula (I) exert antiphlogistic effects and can be used in the therapy for the treatment of inflammations.
413492
Aranyi Peter
Boor Anna
Fekete Gyogy
Gorog Sandor
Hajos Gyogy
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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