3-chloropregnane derivatives and a process for preparing same

Details 3-chloropregnane derivatives and a process for preparing same 3-chloropregnane derivatives and a process for preparing same

C - Chemistry, Metallurgy

07

J

260/15

C07J 71/00 (2006.01)

Patent

CA 1202299

ABSTRACT OF THE DISCLOSURE New .DELTA.1,3,5-3-chloro-pregnane derivatives of the general formula (I), Image (I) wherein X is hydrogen atom, acetyl group or a chloroacetyl group, and Y and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of them is other than hydrogen, are prepared by reacting a .DELTA.1,4-3-oxo-pregnane de- rivative of the general formula,(II), Image (II) wherein X' is acetyl group or a chloroacetyl group and Y and Z are as defined above, with a chloromethyl- -2- eneiminium salt of the general formula (III), Image (III) wherein A(-) is a salt-forming anion, in an aprotic solvent in the presence of a tertiary base, and, if desired, subjecting the resulting product to hydro- lysis. The compounds of the general formula (I) exert antiphlogistic effects and can be used in the therapy for the treatment of inflammations.

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