3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives

Details 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4545 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2680104

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 ( mGluR2 ) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are centralnervous system disorders selected from the group of anxiety,schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

La présente invention porte sur de nouveaux composés, en particulier de nouveaux dérivés de pyridinone selon la Formule (I) comprenant n'importe quelle forme stéréochimiquement isomère de ceux-ci, ou sur un sel pharmaceutiquement acceptable de ceux-ci ou un solvate de ceux-ci, où tous les radicaux sont définis dans la description et les revendications. Les composés selon l'invention sont des modulateurs allostériques positifs de récepteurs métabotropiques du glutamate sous-type 2 (<= mGluR2 >=) utiles dans le traitement ou la prévention de troubles neurologiques et psychiatriques associés au dysfonctionnement du glutamate et de maladies dans lesquelles le sous-type mGluR2 des récepteurs métabotropiques est mis en jeu, en particulier des troubles du système nerveux central dont l'anxiété, la schizophrénie, la migraine, la dépression et l'épilepsie. L'invention porte également sur des compositions pharmaceutiques et des procédés pour préparer de tels composés et de telles compositions, ainsi que sur l'utilisation de tels composés pour la prévention et le traitement de maladies dans lesquelles mGluR2 est mis en jeu.

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