3-cyanoquinolines as inhibitors of egf-r and her2 kinases

Details 3-cyanoquinolines as inhibitors of egf-r and her2 kinases 3-cyanoquinolines as inhibitors of egf-r and her2 kinases

C - Chemistry, Metallurgy

07

D

C07D 215/54 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07D 215/56 (2006.01)

Patent

CA 2467573

This invention provides compounds of Formula (I), represented by the structure wherein G1, G2, G3, G4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

L'invention concerne des composés de formule (I), représentés par la structure dans laquelle G¿1?, G¿2?, G¿3?, G¿4?, Z, X et n sont définis dans la description, ou un sel de ces composés, acceptable sur le plan pharmaceutique, qui sont utiles en tant qu'agents antitumoraux et dans le traitement de maladie polykystique des reins.

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