3-cyclyl-5-(nitrogen-containing 5-membered ring)...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/14 (2006.01) A61K 31/422 (2006.01) A61K 31/454 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2477344

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in- vivo-hydrolysable ester thereof, (I) wherein -N-HET is, for example, (Ic) or (If) wherein R1 is (1-4C)alkyl;Q is selected from, for example, Q1 (Q1) wherein R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, (TC12b) wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

La présente invention a trait à des composés chimiques de formule (I), ou un sel pharmaceutiquement acceptable, ou un ester hydrolysable in vivo de ceux-ci, formule dans laquelle : N-HET est, par exemple, de formule (Ic) ou (If), où R1 est un groupe alkyle en C¿1?-C¿4 ?; Q est choisi parmi, par exemple, la formule (Q1), où R?2¿ et R?3¿ sont indépendamment hydrogène ou fluoro ; T est choisi parmi un gamme de groupes, par exemple, de formule (TC12b), où m est 0, 1 ou 2. Lesdits composés sont utiles en tant qu'agents antibactériens. L'invention a trait également aux procédés de fabrication desdits composés et des compositions pharmaceutiques les contenant.

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