3-de-o-methyl-2'-n-acyl and alkyl fortimicins a and b

Details 3-de-o-methyl-2'-n-acyl and alkyl fortimicins a and b 3-de-o-methyl-2'-n-acyl and alkyl fortimicins a and b

C - Chemistry, Metallurgy

07

H

260/300, 260/360

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1126742

ABSTRACT 3-De-O-methyl -2'-N-acyl and alkyl fortimicin B derivatives represented by the formula Image wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N, N- iloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminolower- alkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N, N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N- loweralkylaminohydroxyloweralkyl,N,N-diloweralkylamino- hydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monolower- alkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminolower- alkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxylower- alkyl, N-loweralkylaminohydroxyloweralkyl, N,N-dilower- alkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds in this invention are useful as antibiotics.

314078

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