3-deoxy-mannosamine derivatives and process for their...

Details 3-deoxy-mannosamine derivatives and process for their... 3-deoxy-mannosamine derivatives and process for their...

C - Chemistry, Metallurgy

07

H

C07H 5/06 (2006.01) A61K 31/70 (2006.01) C07H 5/02 (2006.01) C07H 7/02 (2006.01) C07H 13/04 (2006.01)

Patent

CA 2075336

ABSTRACT The present invention relates to 3-deoxy-derivatives of D-mannosamine of formula Image (I) wherein R is -NH2 or a C2-C5 alkanoyl-NH- or CF3CONH- group; each of R1 and R2 independently is C1-C4 alkyl, or R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy, and R2 is hydrogen or both of R1 and R2 are fluorine; and wherein, when R1 is methoxy and R2 is hydrogen then R is other than -NH2, or a pharmaceutically acceptable salt thereof, which are useful as angiogenesis inhibi- tors, in particular as development of metastasis in- hibitors.

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