3-deoxyglucosone and skin

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 31/00 (2006.01) A61K 31/155 (2006.01) A61K 31/185 (2006.01) A61K 31/198 (2006.01) A61K 31/275 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/4965 (2006.01) A61K 31/505 (2006.01) A61K 39/395 (2006.01) A61P 17/00 (2006.01) A61P 39/06 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2482705

The invention relates to the discovery that 3-deoxyglucosone (3DG) and other alpha-dicarbonyl sugars associated diseases and disorders are present and produced in the skin. Further, the invention relates to the discovery that amadorase, an enzyme that mediates 3DG synthesis, is also present in the skin. Thus, the invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha~dicarbonyl sugars in skin thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.

Cette invention traite du fait que le 3-désoxyglucosone (3DG) ainsi que d'autres sucres alpha-dicarbonylés associés à des maladies et à des troubles sont présents et produits dans la peau. Cette invention traite également du fait que l'amadorase, qui est une enzyme qui induit la synthèse du 3DG, est également présente dans la peau. Cette invention concerne donc des méthodes permettant d'inhiber la production et la fonction du 3-désoxyglucosone et autres sucres alpha-dicarbonylés dans la peau, ce qui permet de traiter ou de prévenir un certain nombre de maladies, troubles ou états. En outre, cette invention porte sur le traitement de divers maladies, troubles ou états associés au stress oxydatif ou induits par celui-ci du fait que le 3DG induit la formation d'espèces oxygénées radicalaires (ROS) ainsi que de produits terminaux avancés de glycation (AGE), qui sont associés à la réponse inflammatoire provoquée par le stress oxydatif.

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