3'-deoxyribonucleotide derivatives

Details 3'-deoxyribonucleotide derivatives 3'-deoxyribonucleotide derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/10 (2006.01) C07H 19/04 (2006.01) C07H 19/14 (2006.01) C07H 19/20 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2266031

3'-Deoxyribonucleotide derivatives represented by the following general formula [I]: Q-V-(CH2)n-NR-R wherein Q represents a 3'-deoxyribonucleotide residue; n is an integer of 4 or more; V represents -CC- or -CH=CH-; and R represents a fluorescent group. Because of having been improved in the uptake efficiency by RNA polymerases, these derivatives are useful as terminators in DNA base sequencing methods with the use of RNA polymerases.

L'invention porte sur des dérivés de 3'-désoxyribonucléotide représentés par la formule [I]: Q-V-(CH¿2?)¿n?-NR-R dans laquelle Q représente un reste de 3'-désoxyribonucléotide; n est un nombre entier égal ou supérieur à 4; V représente -C?C- ou -CH=CH-; et R représente un groupe fluorescent. Du fait de l'amélioration apportée à la capacité d'absorption des ARN polymérases, ces dérivés sont utiles comme terminateurs dans les procédés de séquençage à base d'ADN à l'aide des ARN polymérases.

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