3-descladinose 6-o-substituded erythromycin derivatives

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 17/00 (2006.01) C07H 17/08 (2006.01)

Patent

CA 2301642

Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula selected from the group consisting of (I), (II), (III), (IV) and (V), compositions comprising a therapeutically eff ective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically effective amount of a compound of formulas (I)-(V).

L'invention concerne de nouveaux composés d'érythromycine multicycliques, ainsi que leurs sels et leurs esters pharmaceutiquement acceptables. Ces composés, qui présentent une activité bactéricide, sont représentés par une formule choisie dans le groupe composé par (I), (II), (III), (IV), et (V). L'invention concerne également des compositions renfermant une quantité thérapeutiquement efficace d'un composé de cette invention, associé à un excipient pharmaceutiquement acceptable. L'invention concerne enfin un procédé de traitement des infections bactériennes par administration à un mammifère d'une composition pharmaceutique renfermant une quantité thérapeutiquement efficace d'un composé des formules (I) à (V).

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