3'-end blocked oligonucleotides

Details 3'-end blocked oligonucleotides 3'-end blocked oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2102804

ABSTRACT OF THE DISCLOSURE The invention provides oligonucleotides having 3'- ends blocked by cap structures and having one or more artificial internucleoside linkage. Such oligonucleotides are resistant to in vivo degradation and extension, and thus have superior half-life in vivo.

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