3-guanidinocarbonyl-1-heteroaryl-indole derivatives,...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/404 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61P 9/00 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2492427

The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-indole derivatives of the formula (I) in which R1 to R5 and Ar have the meaning stated in the claims. The inventive compounds are suitable for example as antiarrhytmic medicaments with cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhytmias and of heart failure.

L'invention concerne des dérivés de 3-guanidinocarbonyle-1-hétéroaryle-indole de la formule (I), dans laquelle R1 à R5 et Ar ont la signification qui leur a été attribuée dans les revendications. Les composés selon l'invention sont appropriés, par exemple, comme médicaments antiarythmisants avec un composant cardioprotecteur de prévention et de traitement de l'infarctus ainsi que de traitement de l'angine de poitrine. Ils inhibent également de manière préventive les processus physiopathologiques accompagnant le développement de lésions induites par l'ischémie, en particulier lors du déclenchement d'arythmies cardiaques induites par l'ischémie et d'insuffisance cardiaque.

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