3-(guanidinocarbonyl)heterocycle derivatives, preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2528382

The present invention relates to the novel compounds of the formula (I) and their pharmaceutically acceptable salts. The inventive compounds are suitable, for example, as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiologicaI processes associated with the development of ischemia- induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.

L'invention concerne des nouveaux composés de formule (I) et leurs sels acceptables au plan pharmaceutique. Les composés de l'invention conviennent, par exemple, en tant que médicaments anti-arythmisants comportant un composant cardioprotecteur pour la prophylaxie et le traitement de l'infarctus et pour le traitement de l'angine de poitrine. Ils inhibent également, de manière préventive, les processus physiopathologiques associés au développement de dommages induits par l'ischémie, notamment dans le déclenchement d'arythmies cardiaques induites par l'ischémie et de l'insuffisance cardiaque.

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