3-(heteroaryl-oxy)-2-alkyl-1-aza-bicycloalkyl derivatives as...

C - Chemistry – Metallurgy – 07 – D

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C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/00 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2570155

The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I) wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acelylcholine receptors (NACHR) ligands.

L'invention concerne des dérivés 1-aza-bicycloalkyle de la formule (I) dans laquelle les substituants ont la notation définie dans la description de l'invention, des procédés permettant leur production, leur utilisation en tant qu'agents pharmaceutiques dans la prévention et dans le traitement de troubles psychotiques et neurodégénératifs. Les composés revendiqués font office de ligands de récepteurs nicotiniques de l'acéthylcholine (NACHR).

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