3-heteroarylidenyl-2-indolinone compounds for modulating...

Details 3-heteroarylidenyl-2-indolinone compounds for modulating... 3-heteroarylidenyl-2-indolinone compounds for modulating...

A - Human Necessities

01

N

A01N 43/38 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2357042

The present invention relates to 3-heteroarylidenyl-2-indolinone compounds that modulate the enzymatic activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer. Furthermore, these compounds are expected to enhance the efficacy of other chemotherapeutic agents, in particular, fluorinated pyrimidines, in the treatment of cancer.

La présente invention concerne des composés de 3-hétéroarylidényl-2-indoline qui modulent l'activité enzymatique des protéines kinase et devraient donc convenir pour la prévention et le traitement de maladies cellulaires en rapport avec la protéine kinase telle que le cancer. De plus, ces composés devraient améliorer l'efficacité d'autres agents chimiothérapeutiques, en particulier des pyrimidines fluorées, dans le traitement du cancer.

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