3-hydroquinazolin-4-one derivatives for use as stearoyl coa...

Details 3-hydroquinazolin-4-one derivatives for use as stearoyl coa... 3-hydroquinazolin-4-one derivatives for use as stearoyl coa...

C - Chemistry, Metallurgy

07

D

C07D 239/91 (2006.01) A61K 31/517 (2006.01) A61P 3/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2683925

The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

La présente invention concerne des dérivés de 3-hydroquinazolin-4-one destinés à être utilisés comme inhibiteurs de stéaroyl-CoA désaturase. Ces composés sont utiles dans le traitement et/ou la prévention de diverses maladies humaines, médiées par des enzymes stéaroyl-CoA désaturases (SCD), en particulier des maladies liées à des taux de lipides anormaux, le cancer, les maladies cardiovasculaires, le diabète, l'obésité, le syndrome métabolique et similaire.

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