3-hydroquinazolin-4-one derivatives for use as stearoyl coa...

Details 3-hydroquinazolin-4-one derivatives for use as stearoyl coa... 3-hydroquinazolin-4-one derivatives for use as stearoyl coa...

C - Chemistry, Metallurgy

07

D

C07D 239/91 (2006.01) A61K 31/517 (2006.01) A61P 3/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2740389

The present invention discloses 3-hydroquinazolm-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

Cette invention concerne des dérivés de 3-hydroquinazoline-4-one utilisés comme inhibiteurs de stéaryl-ACP désaturase. Les composés sont utilisés dans le traitement et/ou la prévention de différentes maladies chez lhomme, associées avec les enzymes stéaryl-ACP désaturase, en particulier les maladies associées à des taux anormaux de lipides, le cancer, les maladies cardiovasculaires, le diabète, lobésité, le syndrome métabolique.

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