C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/244, 260/356
C07D 311/30 (2006.01) A61K 31/35 (2006.01)
Patent
CA 1253511
-19- ABSTRACT OF THE DISCLOSURE This invention relates to quercetin or fisetin derivatives substituted on the oxygen in the 3 position by groups such as lower alkyl, cycloalkyl, methanesulfonyl or paratoluenesulfonyl. The derivatives substituted by methanesulfonyl or paratoluenesulfonyl are obtained from a 3-0-glycoside whose phenol OH groups are blocked in the form of benzoate, and from which the OH in the 3 position is released by the action of concentrated HCl; this OH is esterified by mesityl chloride or paratoluenesulfonic acid chloride, and the benzoate groups are eliminated by soda treatment. The O derivatives substituted by alkyl or cycloalkyl are prepared from a suitably substituted acetonitrile or metadipnenol; the resulting derivative reacts with 3,4-dibenzyloxybenzoic acid and the resulting flavone is debenzylated by hydrogenolysis. The derivatives, object of this invention, are useful in preventive or curative therapy of ocular and nervous complications from diabetes and are also useful as hypolipidemic or hypoglycemic agents.
450973
Creuzet Marie-Helene
Feniou Claude
Guichard Francoise
Mosser Jacqueline
Pontagnier Henri
Asta Medica
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
3-hydroxyflavones; their preparation and therapeutic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-hydroxyflavones; their preparation and therapeutic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-hydroxyflavones; their preparation and therapeutic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1175252