3-(imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors

Details 3-(imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors 3-(imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4172 (2006.01) A61K 31/4174 (2006.01) A61K 31/4178 (2006.01) A61P 7/02 (2006.01) C07D 233/54 (2006.01) C07D 401/04 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2472238

Compounds according to formula (I) wherein n is 0-3, R1 is optionally substituted C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen and optionally substituted C 1-6 alkyl, or R5 and R8 are an alkylene chain, are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition.

L'invention concerne de nouveaux composés de formule (I) dans laquelle : n représente un nombre entier compris entre 1 et 3 ; R?1¿ représente un alkyle en C¿1-6?, un alkényle en C¿2-6? ou un alkynyle en C¿2-6? éventuellement substitué, un hétérocycle, un hétérocycle aromatique, un aryle ou hydrogène ; et R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿ et R?9¿ sont sélectionnés indépendamment les uns des autres entre hydrogène et un alkyle en C¿1-6? éventuellement substitué, ou R?5¿ et R?8¿ représentent une chaîne alkylène. Ces composés servent à traiter des états thrombotiques ainsi que d'autres pathologies associées au dépôt de fibrine.

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