3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/06 (2006.01) A61K 31/4178 (2006.01) A61P 7/02 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2472239

Compounds according to formula (I) wherein n is 1-4, R1 is optionally substituted C1-6alkyl, C2-6alkenyl, or C2-6alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7 and R8 are each independently selected from hydrogen and optionally substituted C1-6 alkyl are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition. (1).

L'invention concerne de nouveaux composés de formule (I) dans laquelle : n représente un nombre entier compris entre 1 et 4 ; R?1¿ représente un alkyle en C¿1-6?, un alkényle en C¿2-6? ou un alkynyle en C¿2-6? éventuellement substitué, un hétérocycle, un hétérocycle aromatique, un aryle ou hydrogène ; et R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, et R?8¿ sont sélectionnés indépendamment les uns des autres entre hydrogène et un alkyle en C¿1-6? éventuellement substitué. Ces composés servent à traiter des états thrombotiques ainsi que d'autres pathologies associées au dépôt de fibrine.

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