3-(imidazolyl)-pyrazolo[3,4-b]pyridines

Details 3-(imidazolyl)-pyrazolo[3,4-b]pyridines 3-(imidazolyl)-pyrazolo[3,4-b]pyridines

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/496 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2687625

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 3-imidazoyl-pyrazolo[3,4-b]pyridine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

La présente invention concerne des composés qui agissent comme de puissants antagonistes du récepteur CCR1 et qui présentent une activité anti-inflammatoire in vivo. Les composés sont des dérivés de 3-imidazolyl-pyrazolo[3,4-b]pyridine et sont utiles dans des compositions pharmaceutiques, des procédés de traitement de maladies médiées par le CCR1, et comme contrôles dans des tests pour l'identification d'antagonistes compétitifs du CCR1.

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