C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01) C07D 413/02 (2006.01) C07D 417/06 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2161768
A compound of formula (I), wherein Z is hydrogen, -CH3, or -C2H5; X and Y are represented by -OH, a physi- ologically acceptable ester, or a physiologically acceptable amide; R is represented by from 1 to 3 substitutents inde- pendently chosen from the group: hydrogen, C1-4 alkyl, C1-4 alkoxy, halogen, CF3, or -OCF3; R1 is represented by from 1 to 3 substitutents independently chosen from the group: hydrogen, amino, C1-4 alkyl, C1-4 alkoxy, halogen, CF3, or -OCF3; and pharmaceutically acceptable addition salts thereof. These 3-indolyl-3-yl-propenoic acid deriva- tives are useful as NMDA antagonist.
Un composé de formule (I) où Z représente l'hydrogène, -CH3, ou -C2H5; X et Y représentent -OH, un ester physiologiquement acceptable ou un amide physiologiquement acceptable; R représente 1 à 3 substituants choisis indépendamment parmi les suivants : hydrogène, alkyle en C1-4, alkoxy en C1-4, halogène, CF3 ou -OCF3; R1 représente 1 à 3 substituants choisis indépendamment parmi les suivants : hydrogène, amino, alkyle en C1-4, alkoxy en C1-4, halogène, CF3 ou -OCF3; et leurs sels d'addition pharmaceutiquement acceptables. Ces dérivés de l'acide 3-indolyl-3-yl-propénoïque sont utiles comme antagonistes du NMDA.
Baron Bruce M.
Harrison Boyd L.
Salituro Francesco G.
Aventisub II Inc.
Osler Hoskin & Harcourt Llp
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