C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2589127
The present invention relates to a compound of formula (I) wherein R1 is H, C1- C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy groups and R3 is indolyl or azaindolyl which may carry one or two substituents independently selected from C1-C6- alkyl, C1-C6-alkoxy, phenyl, OH, halogen, NH2, C1-C6-alkylamino, di-C1-C6- alkylamino, heteroaryl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and heterocyclyl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula 1 and of the salts thereof. The compounds of formula (I) are suitable for controlling angiogenesis.
L'invention concerne un composé représenté par la formule (I), dans laquelle R1 représente H, C1-C6-alkyle, phényl-C1-C4-alkyle ou phényle, R2 représente un groupe phényle substitué par 2 ou 3 groupes C1-C6-alcoxy, et R3 représente indolyle ou azaindolyle qui peuvent chacun porter un ou deux substituants sélectionnés individuellement parmi C1-C6-alkyle, C1-C6-alcoxy, phényle, OH, halogène, NH2, C1-C6-alkylamino, di-C1-C6-alkylamino, hétéroaryle avec 5 ou 6 atomes cyclique contenant 1 ou 2 hétéroatomes sélectionnés individuellement parmi O, N, et S et hétérocyclyle à 5 ou 6 atomes cycliques contenant 1 ou 2 hétéroatomes individuellement sélectionnés parmi O, N, et S et les sels de ceux-ci physiologiquement acceptables, ainsi que les solvates physiologiquement acceptables des composés de formule (I) et les sels de ceux-ci. Les composés de formule (I) permettent de lutter contre l'angiogenèse.
Dannhardt Gerd
Kramb Jan-Peter
Peifer Christian
Plutizki Stanislav
Deeth Williams Wall Llp
Johannes Gutenberg-Universitat Mainz
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