3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as...

Details 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as... 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/404 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2417277

The present invention relates to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I), wherein R1 to R6 have the value given in the specification. The compounds are useful as inhibitors of glycogen synthase kinase-3.beta. and, therefore, may be used for the treatment of GSK-3.beta. mediated diseases.

La présente invention concerne des dérivés de 3-indolyl-4-phényl-1H-pyrrole-2,5-dione représentés par la formule (I), dans laquelle R?1¿ à R?6¿ ont la valeur spécifiée dans le descriptif. Ces composés sont utiles en tant qu'inhibiteurs de la glycogène synthase kinase-3.beta. et peuvent être utilisés pour le traitement des maladies induites par GSK-3.beta..

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