3-indolyl thioacetate derivatives

Details 3-indolyl thioacetate derivatives 3-indolyl thioacetate derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2081330

3-Indolyl thioacetate derivatives which are NMDA antagonists, of formula (I): Image in which Z is represented by H, alkyl, phenyl, substituted phe- nyl, or an alkylphenyl substituent in which the phenyl ring may be optionally substituted; X is represented by S, SO, or SO2; m is represented by an integer from 1 to 4; R is represented by hydrogen, halogen, alkyl, alkoxy, CF3, OCF3, OH, NO2, or CN; R1 and R2 are each independently represented by -OH, -OR3, -NR4R5, -OCH2OR3, or -O-(CH2)n-NR6R7, in which n is an integer from 1 to 4; R3 is represented by alkyl, phenyl, substituted phenyl or an alkylphenyl substituent in which the phenyl ring may be option- ally substituted; R4 and R5 are each independently represented by hydrogen or an alkyl; R6 and R7 are each independently repre- sented by hydrogen or alkyl or R6 and R7 together with the adja- cent nitrogen atom form a piperidino, morpholino or pyrrolidino group; and the pharmaceutically acceptable addition salts there- of.

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