3-(iodophenoxymethyl) carbapenem antibacterials

Details 3-(iodophenoxymethyl) carbapenem antibacterials 3-(iodophenoxymethyl) carbapenem antibacterials

C - Chemistry, Metallurgy

07

D

C07D 477/14 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2302009

The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with an iodo-substituted phenyl linked through a CH2-O- group. The compounds of the invention are represented by formula (I). Salts and hydrates thereof are included. The iodo- substituted phenyl ring is further substituted with various substituent groups including at least one cationic group. Pharmaceutical compositions and methods of treatment are also included.

L'invention concerne des agents antibactériens du type carbapenem, dans lesquels le noyau carbapenem est substitué en position 2 avec un phényle iodo substitué, lié par un groupe CH¿2?-O. Les composés de l'invention sont représentés par la formule (I). L'invention porte aussi sur les sels et les hydrates desdits agents. De plus, le cycle phényle iodo est substitué par différents groupes de substituants dont au moins un groupe cationique. Des compositions pharmaceutiques et des procédés de traitement sont également décrits.

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