3-methylflavone-8-carboxylic acid esters

Details 3-methylflavone-8-carboxylic acid esters 3-methylflavone-8-carboxylic acid esters

C - Chemistry, Metallurgy

07

D

260/272, 260/279

C07D 405/12 (2006.01) C07D 311/30 (2006.01) C07D 407/12 (2006.01) C07D 451/12 (2006.01) C07D 453/02 (2006.01)

Patent

CA 1221969

ABSTRACT: 3-Methylflavone-8-carboxylic acid esters I are provided. They may be prepared by condensing a 3- -methylflavone-8-carboxylic acid halide (preferably the chloride) with an aminoalcohol ZOH. Condensation conditions are (a) no solvent, 140-200°C, excess flavone derivative or (b) organic solvent, 0°C to reflux, equimolar reactant proportions, hydrogen halide acceptor optional. The esters have muscle relaxant and calcium blocking action. They are also anaesthetics and anti-inflammatory agents. Image (I) z =Nmethylpiperidyl, tropyl, quinuclidyl or Image (II) n = 0,1 R = H,Ph,C1-C4alkyl R1= H, C1-C4alkyl or Image R2= H, OH R3= H, C1-C4alkyl

406549

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