3'-n-modified 6-o-substituted erythromycin ketolide...

C - Chemistry – Metallurgy – 07 – H

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C07H 17/08 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2303930

Novel 3'-N-modified 6-O-substituted erythromycin ketolide compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I), (II), (III), (IV) or (V), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

Nouveaux dérivés d'érythromycine cétolidée, modifiés en 3'-N et substitués en 6-O, ainsi que leurs sels et leurs esters pharmaceutiquement acceptables, possédant une activité antibactérienne, de formule (I), (II), (III), (IV) ou (V); compositions renfermant une quantité, efficace sur le plan thérapeutique, d'un composé de l'invention, associé à un véhicule pharmaceutiquement acceptable; et méthode permettant de traiter des infections bactériennes en administrant à un mammifère une composition pharmaceutique qui contient une quantité, efficace sur le plan thérapeutique, d'un composé de l'invention.

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