3-¬n-phenylacetylaminopiperidine|-2,6 dion and process of...

Details 3-¬n-phenylacetylaminopiperidine|-2,6 dion and process of... 3-¬n-phenylacetylaminopiperidine|-2,6 dion and process of...

C - Chemistry, Metallurgy

07

D

167/232, 260/292

C07D 211/88 (2006.01) A61K 31/195 (2006.01) A61K 31/445 (2006.01) C07K 4/12 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1262907

3-[N-PHENYLACETYLAMINOPIPERIDINE]-2,6 DION AND PROCESS OF SYNTHESIZING SAME Abstract Disclosed is a compound 3-[N-phenyl-acetylamino- piperidine]-2, 6-dion and the pharmaceutically acceptable salts thereof, and the process for synthesizing same, which process comprises the steps of providing a quantity of L-glutamine, providing a quantity of phenylacetyl halide, mixing together the L-glutamine and phenyl acetyl halide in a weakly alkaline aqueous solution to provide an aqueous reaction mixture, reacting the reaction mixture for a period of time to form the reaction product 3-[N-phenylacetylamino- piperidine]-2, 6-dion, and recovering from the reaction mixture the product 3-[N-phenylacetylaminopiperidine]-2, 6-dion, and when desired preparing the pharmaceutically acceptable salts thereof.

475098

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