3'-or 2'-hydroxymethyl substituted nucleoside derivatives...

Details 3'-or 2'-hydroxymethyl substituted nucleoside derivatives... 3'-or 2'-hydroxymethyl substituted nucleoside derivatives...

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) A61K 31/7064 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61K 31/708 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2404639

The present invention relates to a composition for and a method of treating hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, hepatitis D virus (HDV) infection or a proliferative disorder in a patient using an effective amount of a compound selected from the group consisting of formulas (I)-(IV) below and mixtures of two or more thereof, wherein the substituents are as defined herein. Pharmaceutical compositions comprising these compounds in combination with other HBV, HCV, or HDV agents is also disclosed.

La présente invention porte sur une composition et sur un procédé visant à traiter un patient infecté par les virus de l'hépatite B, de l'hépatite C ou de l'hépatite D, ou souffrant d'une maladie proliférative, au moyen d'une quantité effective d'un composé sélectionné dans le groupe comprenant les formules (I)-(IV) ci-dessous et des mélanges de deux ou plus de ces composés, formules dans lesquelles les substituants sont tels que définis dans la demande. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés en combinaison avec d'autres agents relatifs aux virus de l'hépatite B, C ou D.

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