3-ox(adi)azolylpropanohydroxamic acids useful as procollagen...

Details 3-ox(adi)azolylpropanohydroxamic acids useful as procollagen... 3-ox(adi)azolylpropanohydroxamic acids useful as procollagen...

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61P 17/00 (2006.01) C07D 263/16 (2006.01) C07D 263/32 (2006.01) C07D 263/34 (2006.01) C07D 263/48 (2006.01) C07D 271/07 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2432643

Compound of formula (I), wherein X is C1-6 alkylene or C2-6 alkenylene, each of which is optionally substituted by one or more flluorine atoms; R is aryl or C3-8 cycloalkyl optionally substituted by one or more fluorine atoms; W is N or CZ; are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP.

L'invention concerne un composé représenté par la formule (I), dans laquelle X représente C1-6 alkylène ou C2-6 alcénylène, chacun d'eux étant éventuellement substitué par un ou plusieurs atomes de fluor; R représente aryle ou C3-8 cycloalkyle éventuellement substitué avec un ou plusieurs atomes de fluor; W représente N ou CZ. Les composés décrits dans cette invention sont des inhibiteurs de la procollagène C-protéinase (PCP) utiles pour le traitement d'affections induites par la PCP.

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