3-oxadiazolyl-1,6-naphthyridine derivatives

Details 3-oxadiazolyl-1,6-naphthyridine derivatives 3-oxadiazolyl-1,6-naphthyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2104267

-72- ABSTRACT OF THE DISCLOSURE: 3-Oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphthyridine derivative of the formula (I): Image (I) wherein Het is an oxadiazole ring, R1 is hydrogen atom, an acyl group, a lower alkyl group or a group of the formula: -CH2R1'(in which R1' is a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, benzyl group, aryl group or a heteroaromatic group), R2 is a lower alkyl group, a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, aryl group, a heteroaromatic group, a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a phenoxy group or a lower alkylthio group, or a pharmaceutically acceptable acid addition salt thereof, which are useful as benzodiazepine receptor agonist.

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