3-oxo-indazole-squaric acid derivatives

Details 3-oxo-indazole-squaric acid derivatives 3-oxo-indazole-squaric acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/4188 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2619851

The invention relates to novel squaric acid compounds of formula (I), wherein R1, R2, R2', R2'' and X have the designations cited in patent claim 1. Said compounds can be inhibitors of CHK1 CHK2 and SGK kinases, and can be used to treat diseases and illnesses such as cancer, diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonal hypertonia, cardiovascular diseases and kidney diseases, generally for all types of fibroses and inflammatory processes.

L'invention concerne de nouveaux composés d'acide quadratique de formule (I), dans laquelle R1, R2, R2', R2'' et X ont les significations indiquées dans la revendication 1, lesquels composés sont des inhibiteurs des kinases CHK1-, CHK2- et SGK et peuvent être utilisés dans le traitement de maladies et d'affections telles que le cancer, le diabète, l'obésité, le syndrome métabolique (dyslipidémie), l'hypertonie systémique et pulmonaire, les maladies cardiovasculaires et les maladies rénales, généralement pour tout type de fibroses et de processus inflammatoires.

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