C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/395 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2142700
A compound of general formula (I) is disclosed as useful in treating disorders of the central nervous system wherein R1 is selected from any of alkyl (C1-C12), cycloalkyl (C3-C10), phenyl, substituted phenyl, aralkyl and substituted aralkyl, a heterocyle and a substituted heterocyle; R2 is selected from any of hydrogen, alkyl (C1-C12), cycloalkyl (C3- C10), aralkyl and substituted aralkyl; R is selected from one or more of hydrogen, alkyl (C1-C12), branched alkyl (C3- C8), halogens, perfluoro (lower alkyl), hydroxy, lower alkoxy, di(loweralkyl)amino, lower alkoxycarbonyl or lower alkylthio; n is selected from zero or 1; A is selected from methylene or substituted methine; R3 and R4 are independently selected from hydrogen, alkyl (C1-C3) or may be taken together to form a double bond within the ring; X is selected from oxygen or sulfur; crud Y is selected from NH, oxygen or sulfur, provided that when R1 is an alkyl or a heterocycle or substituted heterocycle, Y may not be sulfur or oxygenl and Y and R1 may also be taken together to form an NH2 group. Pharmaceutical compositions and methods of treatment are also disclosed.
Maryanoff Bruce E.
Mccomsey David F.
Winston Ho
Mcneilab Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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