3-phenyglutarimide derivatives as muscarinic receptor...

Details 3-phenyglutarimide derivatives as muscarinic receptor... 3-phenyglutarimide derivatives as muscarinic receptor...

C - Chemistry, Metallurgy

07

D

C07D 211/88 (2006.01) A61K 31/445 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2067759

Muscarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of formula (I), or a acceptable salt thereof, where m is 1 or 2; R1 and R2 are each independently H or C1-C4 alkyl or together re- present -(CH2)p- where p is an integer of from 2 to 5; R3 is H or C1-C4 alkyl; wherein Z is a direct link, -CH2-, -CH2O- or -CH2S-; and R4 is a group of formulae (II), (III), (IV) or Het, where R5 and R6 are each independently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)nOH, halo, trifluoromethyl, cyano, -(CH2)nNR7R8, -CO(C1-C4 alkyl), -OCO(C1-C4 alkyl), -CH(OH)(C1-C4 alkyl), -C(OH)(C1-C4 alkyl)2,-SO2NH2,-CH2)nCONR7R8 or -(CH2)nCOO(C1-C4 alkyl); R7 and R8 are each independently H or C1-C4 alkyl; n is 0,1 or 2; X and X1 are each independently O or CH2; q is 1, 2 or 3; and "Het" is pyridyl, pyrazinyl or thienyl.

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