3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as...

Details 3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as... 3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as...

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01)

Patent

CA 2216787

This invention relates to the treatment of depression by administration of novel 3-(Rn-phenyl)-1,4-dialkyl-1,2,4-triazolium salts of formula (I), wherein R is halogen, trifluoromethyl, C1-4 lower alkyl or C1-4 lower alkoxy, n is zero, 1 or 2, and R1 and R4 independently represent C1-3 lower alkyl; and A- represents a pharmaceutically acceptable anion.

L'invention concerne le traitement de la dépression par l'administration de nouveaux sels de 3-(R¿n?-phényl)-1,4-dialkyl-1,2,4-triazolium de formule (I), dans laquelle R représente halogène, trifluorométhyle, alkyle inférieur C¿1-4? ou alcoxy inférieur C¿1-4?, n vaut zéro, 1 ou 2, et R¿1? et R¿4? représentent indépendamment alkyle inférieur C¿1-3?; et A?-¿ représente un anion pharmaceutiquement acceptable.

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