3-phenyl-2-arylalkylthiopropionic acid derivatives as...

Details 3-phenyl-2-arylalkylthiopropionic acid derivatives as... 3-phenyl-2-arylalkylthiopropionic acid derivatives as...

C - Chemistry, Metallurgy

07

C

C07C 323/56 (2006.01) A61K 31/192 (2006.01) A61K 31/255 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) C07C 309/66 (2006.01) C07C 319/20 (2006.01)

Patent

CA 2470066

A compound of formula (I); wherein R1 represents chloro, fluoro or hydroxy as well as optical isomers and racemates thereof as well as pharmaceutically acceptable salts, prodrugs, solvates and crystalline forms thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

L'invention concerne un composé de formule (I), dans laquelle R?1¿ représente chlore, fluor ou hydroxy, ses isomères optiques, ses racémates ainsi que ses sels pharmaceutiquement acceptables, ses promédicaments, ses solvates et ses formes cristallines. L'invention concerne également des procédés de préparation desdits composés, leur utilité dans le traitement d'états cliniques notamment des troubles lipidiques (dyslipidémie), associés ou non à une résistance à l'insuline, des procédés pour leur utilisation thérapeutique, ainsi que des compositions pharmaceutiques les contenant.

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